TBE diagnosis can only be verified by means of laboratory techniques. Definitive diagnosis of tick-borne encephalitis is based on
- isolation of the virus from blood or cerebrospinal fluid or from post mortem tissues;
- serological tests for a significant titer increase of IgG or neutralising antibodies in paired sera;
- demonstration of specific IgM in acute serum.
Polymerase chain reaction (PCR) can also be used to amplify viral RNA from blood or liquor samples or from post mortem brain tissues.
- Bjöersdorff A: Borreliosis and tick-borne encephalitis. In: Arthropod-borne Diseases. 2002, Sci. Proc. BSAVA Congress, Birmingham, pp 185-6