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Tick-Borne Encephalitis

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Diagnosis

TBE diagnosis can only be verified by means of laboratory techniques. Definitive diagnosis of tick-borne encephalitis is based on

  • isolation of the virus from blood or cerebrospinal fluid or from post mortem tissues;
  • serological tests for a significant titer increase of IgG or neutralising antibodies in paired sera;
  • demonstration of specific IgM in acute serum.

Polymerase chain reaction (PCR) can also be used to amplify viral RNA from blood or liquor samples or from post mortem brain tissues.

Further information

  • Bj√∂ersdorff A: Borreliosis and tick-borne encephalitis. In: Arthropod-borne Diseases. 2002, Sci. Proc. BSAVA Congress, Birmingham, pp 185-6

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